Non-Functionalized or Hydrophobic Colloidal Silica Nanospheres
 

  • Highly Monodisperse, CV< 3% for all sizes from 20 nm - 1000 nm.

  • Roundness > 0.980.

  • Density: 1.8 - 2.2 g/cm^3.

  • Prepared by the sol-gel process based on the Stöber method for hydrophilic non-functionalized silica nanospheres

  • Surface chemistry:
    Hydroxyl-terminated (-OH) for hydrophilic non-functionalized beads

    Alkane-modified (-CH3) for hydrophobic beads

  • Provided in Milli-Q water at difference concentrations 10 - 100 mg/ml (i.e. 1 - 10 % w/v) for non-functionalized colloidal silica nanospheres.
    Provided in powder form for hydrophobic silica nanospheres that can be well suspended in organic solvents such as DMF and THF. 

  • Lifetime: At least 2 years from the date of product delivery.

  • These silicon dioxide nanoparticles can be easily surface-functionalized via chemical bond formation.

Safety Data Sheets

Hollow Silica Nanospheres

  •  Our analytical-grade non-functionalized or hydrophobic colloidal silica nanospheres can be widely utilized for scientific applications. For instance, 100 nm silicon dioxide (silica) nanoparticles have been frequently used for aggregation tests and colloidal behavior studies, and 1 μm non-functionalized silica nanoparticles are suitable for chemical deposition and other biomedical applications. Silica nanoparticles with an ultra-narrow size distribution are frequently used as a size standard for many applications.

  • These silica nanospheres are ultra-stable in aqueous solutions at room temperature and can be easily adapted to common biological buffers like phosphate-buffered saline (PBS) or organic solvents like ethanol via repeated centrifugation and resuspension.

Transmission/Scanning Electron Micrographs​

20 nm

Alpha Nanotech Silica Nanoparticles 20nm
Alpha Nanotech Silica Nanoparticles 20nm

50 nm

Alpha Nanotech Silica Nanoparticles 50nm
Alpha Nanotech Silica Nanoparticles 50nm

120 nm

120 nm

Silica Nanoparticles 120 nm
Alpha Nanotech Silica Nanoparticles 120nm
Silica Nanoparticles 120 nm
Silica Nanoparticles 120nm

140 nm

Silica Nanoparticles 140nm
Alpha Nanotech Silica Nanoparticles 140nm

160 nm

Alpha Nanotech Silica Nanoparticles 160nm
Alpha Nanotech Silica Nanoparticles 160nm

180 nm

Alpha Nanotech Silica Nanoparticles 180nm
Alpha Nanotech Silica Nanoparticles 180nm

200 nm

200 nm

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Alpha Nanotech Silica Nanoparticles 200nm
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Alpha Nanotech Silica Nanoparticles 200nm

300 nm

300 nm

Silica Nanoparticles 300 nm
Alpha Nanotech Silica Nanoparticles 300nm
Silica Nanoparticles 300 nm
Alpha Nanotech Silica Nanoparticles 300nm

400 nm

Alpha Nanotech Silica Nanoparticles 400nm
Alpha Nanotech Silica Nanoparticles 400nm

500 nm

Alpha Nanotech Silica Nanoparticles 500nm
Alpha Nanotech Silica Nanoparticles 500nm

1000 nm

Alpha Nanotech Silica Nanoparticles 1000nm
Alpha Nanotech Silica Nanoparticles 1000nm

Scanning Transmission Electron Micrographs​

Alpha Nanotech Silica Nanoparticles
Alpha Nanotech Silica Nanoparticles

Fourier-transform infrared spectroscopy (FTIR) Results

(Raw data available upon request)

silica nanopartices

Zeta Potential Measurement Results

(Raw data available upon request)

silica nanoparticles

UV-Vis Spectra

(Raw data available upon request)

silica nanoparticles

After several years of research and development, our synthesis of monodisperse silica nanoparticles has become a mature technology that enables us to precisely controls the particle size from batch to batch. Characterizations have been carried out using various precision instruments such as high-resolution transmission electron microscopy, field emission scanning electron microscopy, particle size analyzer, and ultraviolet–visiblespectroscopy. The series of monodisperse particles have high sphericity, strictly monodisperse particle size, small coefficient of variation and stable physical and chemical properties. Our silica nanoparticles have a nearly perfect sphericity and an extremely narrow particle size distribution. The nanoparticles with a CV value of 3.0%  have extremely stable physicochemical properties, are easy to store, and have good stability. The surface of these spheres is rich in hydroxyl functional groups and is easy to functionalize. Applications of our silica nanoparticles include research and preparation of photonic crystals, synthesis of ordered structural materials, biomedical testing, catalytic carriers, high performance polymer additives, polymer nanocomposite fillers, preparation of advanced ceramics, chemical mechanical polishing.

How do we measure the CV Values and reveal the real size distributions?

Through the years of working with nano-/microspheres, our researchers and technicians fully understand the importance of the size distributions from batch to batch. In the field of size characterizations, there are mainly two methods, scanning/transmission/scanning transmission electron micrographs (SEM/TEM/STEM) and dynamic light scattering (i.e. DLS). Unfortunately, we found DLS are unsuitable for accurately determine the size distributions of nano-/microspheres when compared to SEM/TEM/STEM techniques. 

 

  • DLS results are closely related to colloidal stability, and as an inevitable result, the size distributions will not be accurate for large-sized nanoparticles. For nanoparticles below 100 nm, the hydrodynamic sizes become relevant. However, for nanoparticles around or above a few hundred nanometers, colloidal stability is greatly affected by the role of gravity. In comparison, the SEM/TEM/STEM images are based on dry samples only where higher reproducibility and reliability have been seen through numerous studies in our case and in the literature.

  • DLS cannot distinguish between nanoparticles themselves and the aggregates of surfactants. As most of our colloidal nano-/microspheres have a trace of surfactants purposely added in the system for longer lifetime, DLS becomes unsuitable for direct size measurements unless the nano-/microspheres are washed at least three times with the Milli-Q water or de-ionized water to fully remove any trace of surfactants. Similarly, the nano-/microspheres due to inefficient re-suspension also distort the DLS results; for instance, a couple of aggregated 100 nm nanoparticles might be seen as 200 nm or 300 nm nanoparticles under DLS measurements.

  • DLS cannot give any insight into the shape or the spherical degree of nano-/microspheres. Irregularly-shaped particles and perfectly spherical particles can be interpreted the same under DLS measurements.

As a result, we use SEM/TEM/STEM techniques instead of DLS measurements as our routine quality control method. We routinely take at least 10 electron micrographs and process them with ImageJ for size distributions as well as the CV value. This is also the reason that we typically include a couple of representative SEM/TEM/STEM images with our products when delivered to our clients. We wish to reveal the real size distributions and let the clients visualize the images of nano-/microspheres directly instead of viewing the fitted curves indirectly. 

nanoparticle size measurement

Our Non-Functionalized Silica Nanospheres in Stock:

20 nm

50 nm

100 nm

120 nm

140 nm

160 nm

200 nm

300 nm

400 nm

500 nm

1000 nm

10 ml at 10 mg/ml

$ 95

$ 95

$ 95

$ 95

$ 95

$ 95

$ 85

$ 85

$ 85

$ 85

$ 85

20 ml at 10 mg/ml

$ 150

$ 150

$ 150

$ 150

$ 150

$ 150

$ 135

$ 135

$ 135

$ 135

$ 135

10 ml at 50 mg/ml

$ 320

$ 320

$ 320

$ 320

$ 320

$ 320

$ 280

 

$ 280

 

$ 280

$ 280

$ 280

20 ml at 50 mg/ml

$ 560

$ 560

$ 560

$ 560

$ 560

$ 560

$ 500

$ 500

$ 500

$ 500

$ 500

Notes:
 

1. SDS (Material Safety Data Sheet) and COA (Certificate of Analysis) are included for every purchase. 

2. The prices listed above are in Canadian Dollars (CND$), and please refer to the blow exchange box for the most current daily exchange rates.

3. We accept both online purchases at our online store or Amazon stores and invoiced orders (Net 30 Terms). In-stock items will be dispatched within 1-3 business days. The lead time for customized orders is typically within 10 business days and will be evaluated on a case-by-case basis.

 

4. Shipping Locations for our clients are listed below.
 

Orders destined for the United States will be shipped from one of the two US offices below.

Unit 390, 701 Harrison Ave, Blaine, WA 98230 US

Unit 4, 2045 Niagara Falls Blvd, Niagara Falls, NY 14304 US
 

Orders destined for the UK will be shipped from our UK office.

Office 24743, Courier Point, 13 Freeland Park, Wareham Road, Poole, Dorset, BH16 6FH, UK

Orders destined for Europe will be shipped from our EU office.
Allée Primavera 78, Annecy, Pringy, 74370, France


Orders destined for Canada and other International destinations will be shipped from our Canadian headquarters.
135 - 3800 Wesbrook Mall, University of British Columbia Campus, Vancouver, BC, V6S2L9, Canada


No duties or any additional taxes for the orders delivered to Canadian, US, UK, and EU addresses, regardless of the sales channel. For other International shipping addresses, recipients are responsible for local duties and taxes.

 

5. Free exchanges or full refunds will be offered within 30 days after the order fulfillment without any questions asked if the ordered items fail to meet customer expectations.

Daily Exchange Rates

(updated every 12 hr)

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